Anti-Human Nogo-A Recombinant Antibody (TAB-903)
CAT#: TAB-903
Recombinant humanized (from mouse) antibody expressed in CHO binding to human Nogo-A. It is a monoclonal antibody designed for the treatment of ALS and multiple sclerosis. It targets a protein called Neurite Outgrowth Inhibitor (NOGO-A) or Reticulon 4. NOGO-A is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. NOGO-A is found at higher than normal levels in persons with MND.
Tested Data
Gene Expression
SDS-PAGE
Figure 1 Anti-Human Nogo-A Recombinant Antibody (TAB-903) in SDS-PAGE
SDS-PAGE analysis of TAB-903 in non-reduced (Lane 1) and reduced (Lane 2) conditions.
SEC-HPLC
Figure 2 Anti-Human Nogo-A Recombinant Antibody (TAB-903) in HPLC
HPLC analysis of TAB-903 shows the purity is>95%.
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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in seminiferous ducts cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6_selected.jpg
Normal Tissue
Figure 3 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_A_6_6_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_B_8_5.jpg
Normal Tissue
Figure 5 Cerebellum
Cells in granular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_B_7_8.jpg
Normal Tissue
Figure 6 Colon
Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_9_3.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HHSteC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115310-RTN4
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1
- Species Reactivity
- Human
- Applications
- Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
- MW
- 145.2 kDa
- Related Disease
- Multiple sclerosis (MS)
Product Property
- Purity
- >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
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(Creative Biolabs Cat# TAB-903, RRID: AB_3112019)
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Biosimilar Overview
Please refer to Ozanezumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ozanezumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "RTN4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2437z | Mouse Anti-RTN4 Recombinant Antibody (clone 28B12) | WB, ELISA, IF, IP | Mouse IgM, κ |
| MOB-186CQ | Mouse Anti-RTN4 Antibody | ELISA, WB | Mouse IgG1 |
| HPAB-0294CQ | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6) | ELISA, WB | Mouse IgG1 |
| HPAB-0295CQ | Human Anti-RTN4 Recombinant Antibody (clone h3A6) | ELISA, WB | Human IgG4 |
| VS3-XY3491 | Rabbit Anti-RTN4 Recombinant Antibody (clone R05-4C9) | WB, IHC-P, ICC, IF, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-242 | Anti-Human RTN-4 Recombinant Antibody (TAB-242) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-531MZ | Anti-Human RTN4 Recombinant Antibody (11C7) | ELISA, ICC | |
| TAB-532MZ | Mouse Anti-RTN4 Recombinant Antibody (TAB-532MZ) | ELISA, FC | Mouse IgG |
| TAB-531MZ-S(P) | Anti-Human RTN4 Recombinant Antibody scFv Fragment (11C7) | ELISA, ICC | |
| TAB-531MZ-F(E) | Anti-Human RTN4 Recombinant Antibody Fab Fragment (11C7) | ELISA, ICC | |
| TAB-532MZ-F(E) | Mouse Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-532MZ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-533MZ | Human Anti-RTN4 Recombinant Antibody (TAB-533MZ) | ELISA, FC | Chimeric (mouse/human) IgG |
| TAB-533MZ-S(P) | Mouse Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-533MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-533MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-533MZ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-534MZ | Human Anti-RTN4 Recombinant Antibody (TAB-534MZ) | ELISA, FC | Humanized IgG |
| TAB-535MZ | Human Anti-RTN4 Recombinant Antibody (TAB-535MZ) | ELISA, FC | Humanized IgG |
| TAB-536MZ | Human Anti-RTN4 Recombinant Antibody (TAB-536MZ) | ELISA, FC | Humanized IgG |
| TAB-537MZ | Human Anti-RTN4 Recombinant Antibody (TAB-537MZ) | ELISA, FC | Humanized IgG |
| TAB-534MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-534MZ-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3139 | Hi-Affi™ Recombinant Rabbit Anti-RTN4 Monoclonal Antibody (DS3139AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0294CQ-F(E) | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0295CQ-F(E) | Human Anti-RTN4 Recombinant Antibody (clone h3A6); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0047-WJ-F(E) | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0901-FY-S(P) | Human Anti-RTN4 Recombinant Antibody; scFv Fragment (HPAB-0901-FY-S(P)) | ELISA, Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0294CQ-S(P) | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0295CQ-S(P) | Human Anti-RTN4 Recombinant Antibody (clone h3A6); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-0047-WJ-S(P) | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0901-FY-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (HPAB-0901-FY-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-903 | Afuco™ Anti-RTN4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-903) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-242 | Afuco™ Anti-RTN4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-242) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY158 | Mouse Anti-RTN4 (clone 11C7) scFv-Fc Chimera | ELISA, ICC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC538 | Recombinant Anti-RTN4 Vesicular Antibody, EV Displayed (VS-0425-YC538) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6264 | Anti-RTN4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6265 | Anti-Rat RTN4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6266 | Anti-Mouse RTN4 Immunohistochemistry Kit | IHC |
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